Carvedilol was more effective than metoprolol tartrate for lowering mortality in chronic heart failure
نویسندگان
چکیده
منابع مشابه
Carvedilol was more effective than metoprolol tartrate for lowering mortality in chronic heart failure.
and commentary also appear in ACP Journal Club. Commentary T hanks to the remarkable successes in drug development, a variety of effective treatments are available for most medical conditions. The new challenge is often how to select the optimal therapy. For approval purposes, regulatory agencies require placebo controlled rather than active comparison trials. The federally funded ALLHAT repres...
متن کاملCarvedilol in the treatment of chronic heart failure: Lessons from The Carvedilol Or Metoprolol European Trial
Along with the angiotensin-converting enzyme inhibitors (ACEIs), the beta-adrenergic receptor blockers have gradually emerged to be standard in the therapy of heart failure. Individual beta-blockers that have been shown to reduce all-cause mortality in patients with heart failure include bisoprolol, metoprolol and carvedilol. Carvedilol distinguishes from the other beta-blockers as being a non-...
متن کاملCarvedilol: A Promising Drug Combined with Lipid-lowering Medications for Patients with Hypertension and Heart Failure
Background: Statins frequently cause myopathy especially in combination with fibrates, and physical activity is considered a trigger for the muscle disorder. Elevated plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH) and aldolase, are the main indicators of the severity of myopathy. Carvedilol is commonly used with lipid-lowering drugs in the management of heart failure, hypert...
متن کاملEffects of metoprolol tartrate therapy in patients with heart failure.
OBJECTIVE To study the effects of metoprolol tartrate therapy in patients with heart failure. METHODS Fifty patients (36 males) aged 52+/-14.8 yrs, with functional class II to IV heart failure (HF) and left ventricular ejection fraction (LVFE) < 45%, assessed by radionuclide ventriculography, were evaluated in a retrospective study. Metoprolol tartrate was added to the usual therapy, with a s...
متن کاملCarvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
OBJECTIVES We explored whether vascular protection by carvedilol could contribute to its superior effects in the treatment of heart failure (HF) compared with metoprolol tartrate in the COMET (Carvedilol Or Metoprolol European Trial) study. BACKGROUND Full adrenergic blockade by carvedilol and additional (e.g., antioxidative) properties may lead to vascular protection relative to beta-1 block...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Evidence-Based Medicine
سال: 2004
ISSN: 1356-5524
DOI: 10.1136/ebm.9.1.14